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What are Absorbable Hemostatic Agents and How Do They Work?

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What are Absorbable Hemostatic Agents and How Do They Work?


What is an Absorbable Hemostat?

Absorbable hemostatic agents are useful as adjunctive therapy during surgical procedures when conventional methods do not control surgical bleeding. 1


What Happens During Hemostasis?

  • Hemostasis includes the following steps: 
    • Vascular Spasm or Vasoconstriction
      • Vasoconstriction – The narrowing (constriction) of blood vessels by small muscles in their walls. When blood vessels constrict, blood flow is slowed or blocked.4
    • Platelet formation
      • Platelet formation – Platelets are produced from very large bone marrow cells called megakaryocytes. As megakaryocytes develop into giant cells, they undergo a process of fragmentation that results in the release of over 1,000 platelets per megakaryocyte.5  Platelets contain proteins on their surface that allow them to stick to the injury and to each other.6
    • Clot formation/ Blood Coagulation
      • Clot formation/blood coagulation – A platelet plug is formed and the external bleeding stops. Next, small molecules, called clotting factors, cause strands of blood-borne materials, called fibrin, to stick together and seal the inside of the wound. Eventually, the cut blood vessel heals, and the blood clot dissolves after a few days.

Why are Hemostatic Agents Needed?

Absorbable hemostatic agents are useful as adjunctive therapy during surgical procedures when conventional methods do not control surgical bleeding.1

How Do You Use an Absorbable Hemostatic Agent?

  • Use of an absorbable hemostatic agent will be dependent upon the form factor of the product and should be used in accordance with the manufacturer’s instructions for use.
  • Arista™ AH is a simple to use, absorbable hemostatic powder that is ready to use out of the package and ready to be directly applied to the bleeding site2
  • Hemostasis is completed within minutes2

What is Arista ™ AH Absorbable Hemostat?

  • Arista™ AH is a 100% plant-based absorbable hemostatic powder derived from purified plant starch.2
  • The power of Arista™ AH lies in its Microporous Polysaccharide Hemospheres, a patented blood clotting technology.2

Features and Benefits of Arista™ AH Absorbable Hemostat

Easy to Use: 

  • Arista™ AH is ready on-demand with a 5 year shelf life.2
  • No mixing and no refrigeration are required.2
  • Arista™ AH provides broad area coverage on rough surfaces and in hard-to-reach areas.2

 

Thrombin-Free and 100% Plant-Based

  • Thrombin-free, biocompatible and non-pyrogenic. 2
  • Arista™ AH is 100% plant-based. 2

 

Faster Hemostasis

  • Complete Hemostasis is achieved in minutes. 2
  • The clotting process begins on contact, regardless of a patient’s coagulation status. 2
  • Typically absorbed in 24-48 hours* by amylases. 2,3

When can Arista™ AH Absorbable Hemostat Be Used?

  • Arista™ can be used in a wide variety of surgical procedures (except neurologic and ophthalmic) 2
  • It serves as an adjunctive hemostatic device to assist when control of capillary, venous, and arteriolar bleeding by pressure, ligature, and other conventional procedures are ineffective or impractical. 2

 

Comparison of Arista™ and Surgicel 

  • Please review the Arista va. Surgicel Brochure to learn more.

 

Learn More About Arista™ AH Hemostatic Particles

  • 1.844.8.BD.LIFE (844.823.5433)

References

  1.  Gabay M. Absorbable hemostatic agents. Am J Health Syst Pharm. 2006 Jul 1;63(13):1244-53. doi: 10.2146/ajhp060003. PMID: 16790576.
  2. Arista™ AH Instructions for Use
  3. Data generated in a preclinical study. Data may not correlate to performance in humans. Because there have been reports of decreased amylase activity in newborns up to 10 months, absorption rates of Arista™ AH in this population may be longer than 48 hours.
  4. Vasoconstriction: MedlinePlus Medical Encyclopedia. Retrieved 19 August 2021, from https://medlineplus.gov/ency/article/002338.htm
  5. Encyclopedia, M. (2021). Vasoconstriction: MedlinePlus Medical Encyclopedia. Retrieved 19 August 2021, from https://medlineplus.gov/ency/article/002338.htm
  6. Platelets on the Web, Department of Biostatistics & Epidemiology, College of Public Health, OUHSC https://www.ouhsc.edu/platelets/Platelets/platelets%20intro.html
  7. Encyclopedia, M., & formation, B. (2021). Blood clot formation: MedlinePlus Medical Encyclopedia Image. Retrieved 19 August 2021, from https://medlineplus.gov/ency/imagepages/19462.htm